Garlic sulfur compounds suppress cancerogenesis and oxidative stress

To chci

Garlic has long been considered a food with many health benefits. Several studies have confirmed that sulfur compounds are responsible for the positive effects of garlic on organisms. Garlic acts as an antioxidant by increasing antioxidant enzyme activity, reducing reactive oxygen species generation, and protecting proteins and lipids from oxidation. Garlic suppresses carcinogenesis through several mechanisms: (1) it reduces oxidative stress, and therefore, prevents damage to DNA; (2) it induces apoptosis or cell cycle arrest in cancer cells; and (3) it modifies gene expression through histon acetylation. The positive effects of garlic could be mediated by several mechanisms. It influences signalling pathways of gasotransmitters such as hydrogen sulfide. Garlic enhances hydrogen sulfide production both through its direct release and through an increase in activity of enzymes which produce hydrogen sulfide. Hydrogen sulfide acts as a signalling molecule in various tissues and participates in the regulation of many physiological processes. We can presume that garlic, which is able to release hydrogen sulfide, exhibits effects similar to those of this gasotransmitter. … celý popis

Podrobná bibliografie

Hlavní autor:

Markéta Dvořáková

Další autoři:

Ivona Weingartová, Jan Nevoral, David Němeček, Tereza Krejčová

Typ dokumentu:

Články

Publikováno v:

Scientia agriculturae bohemica. -- ISSN 1211-3174. -- Roč. 46, č. 2 (2015), s. 65-72

Témata:

kuchyňské bylinky

léčivé rostliny

česnek

česnek kuchyňský

léčivé vlastnosti

způsob působení

oxidační stres

karcinogeneze

antioxidanty

enzymatická aktivita

kyslík

volné radikály

peroxidace lipidů

DNA (nukleová kyselina)

poškození

apoptóza

karcinomy

buňky

projev genu

histony

acetylace

sulfan

fyziologická regulace

CULINARY HERBS

DRUG PLANTS

GARLIC

ALLIUM SATIVUM

MEDICINAL PROPERTIES

MODE OF ACTION

Oxidative stress

CARCINOGENESIS

ANTIOXIDANTS

ENZYME ACTIVITY

OXYGEN

FREE RADICALS

LIPID PEROXIDATION

DNA

DAMAGE

APOPTOSIS

CARCINOMA

CELLS

GENE EXPRESSION

HISTONES

ACETYLATION

HYDROGEN SULPHIDE

PHYSIOLOGICAL REGULATION

ROS > reaktivní formy kyslíku > kyslíkové radikály > gasotransmitery

Bibliografie:

Literatura na s. 68-72